This first piece of info does not match other info I have found on the web:
William McGuire was born about 1780 in , of Botetourt, Virginia. He married Elizabeth Adams on Nov 27, 1797.


They had the following children:
1- Frances McGuire who married David Austin

This info seems much more accurate from
http://burelison.com/branches/mcguire_ft.htm
MOSES MCGUIRE was born about 1740 in Ireland. He died in 1796 in Franklin County, Virginia, USA.
married SARAH THOMAS in 1779 in Franklin County, Virginia, USA.
She was born about 1740 in Ireland. She died about 10 Sep 1815 in Ireland.

1800 tax list, Franklin Co., VA District of Richard French:
Stone, James...free tithables....2
horses.......2
slaves over 16........1
1810 census, Franklin Co., VA males 16/26.......1
females under 10..........1
females 16/26..............1
females over 45..........1
slaves.........................1


John McGuire...males 26/45 & family (MR note: neighbors indicate location on Maggodee Creek

Moses MCGUIRE and Sarah THOMAS had the following children:


1- ELIJAH T MCGUIRE SR was born about 1768 in Franklin County, Virginia, USA. He died about 1861 in Franklin County, Virginia, USA. He married SARAH ROBERTSON on 07 Mar 1791 in Franklin County, Virginia, USA, daughter of William ROBERTSON Sr and Phoebe CYLBORNE. She was born in 1768 in Franklin County, Virginia, USA. She died about 1863 in Franklin County, Virginia, USA.
2- SALOME 'SALLY' MCGUIRE was born about 1778 in Virginia, USA. She died after 1820 in Ohio, USA. She married SAMUEL RUDY SR on 02 Sep 1795 in Franklin County, Virginia, USA. He was born on 12 Jul 1770 in Frederick County, Maryland, USA. He died on 14 Sep 1847 in Newberry Township, Miami County, Ohio, USA.
3-JOHN MCGUIRE SR was born before 1750 in Ireland.
He died after 1796 in Franklin County, Virginia, USA.
He married NANCY HAMRICK on 01 Oct 1803 in Franklin County, Virginia, USA, daughter of Joseph Benjamin HAMRICK and Frances OTEY.
She was born about 1770 in Franklin County, Virginia, USA. She died after 1842 in Montgomery County, Virginia, USA.
4- MARY MCGUIRE was born about 1783. She married JOHN CULP SR on 08 Mar 1801 in Franklin County, Virginia, USA.

JOHN MCGUIRE SR (Moses) was born before 1750 in Ireland. He died after 1796 in Franklin County, Virginia, USA.
He married NANCY HAMRICK on 01 Oct 1803 in Franklin County, Virginia, USA, daughter of Joseph Benjamin HAMRICK and Frances OTEY.
She was born about 1770 in Franklin County, Virginia, USA. She died after 1842 in Montgomery County, Virginia, USA.

Notes for John MCGUIRE Sr:
The McGuires (MaGuires) were mostly from County Fermanagh Northern Ireland, although some, because of the turmoil there is the 1600's and 1700's fled to the south.
John is believed to be from Ardfert near Tralee, County Kerry. Also, he and four brothers along with his father and mother sailed from Dublin and arrived at Bermuda Hundred, Charles City County on the Jane and Diana, skippered by Captain Hadwich in October 1789.
It is believed that his family was indentured to Edward McGuire, who in 1747 purchased 346 acres on the Wappomo in Prince George County.
By 1795, John and his family had moved to Franklin County in an area on the North Fork of Giles Creek. About 1815, they moved to Botetourt County.
The McGuires were farmers and earned their living from the soil. W.L. McGuire Sr. Newport News, Virginia - The Montgomery Story

John MCGUIRE Sr and Nancy HAMRICK had the following children:
1-FRANCIS MCGUIRE was born on 07 Jul 1799 in Botetourt County, Virginia, USA.
She died on 19 Mar 1881 in Bedford County, Virginia, USA.
She married DANIEL DAVID AUSTIN on 18 Jun 1834 in Botetourt County, Virginia, USA, son of Isaac R AUSTIN Sr and Martha G MALCOMB.
He was born about 1802 in Botetourt County, Virginia, USA. He died on 10 Mar 1881 in Bedford County, Virginia, USA.
2- SARAH 'SALLY' MCGUIRE was born in Dec 1803 in Franklin County, Virginia, USA. She died about 1906. She married (1) ABRAHAM EVANS JR on 14 Sep 1824 in Botetourt County, Virginia, USA, son of Abraham EVANS Sr and Catherine Elizabeth ENSMINGER. He was born in 1800 in Bath County, Virginia, USA. He died in 1860. She married (2) HARRISON A LOWRY on 17 Apr 1867.
3- ARMSTRONG MCGUIRE SR was born about 1812 in Montgomery County, Virginia, USA. He died about 1870 in Franklin County, Virginia, USA. He married (1) ANN MAHALA HEWITT on 01 May 1833 in Montgomery County, Virginia, USA, daughter of John HEWITT Sr and Pauline 'Polly' LN-UNK. She was born about 1815 in Botetourt County, Virginia, USA. She died on 15 Sep 1853 in Floyd County, Virginia, USA. He married (2) ELIZABETH ANN SIRAH on 15 Jul 1854 in Montgomery County, Virginia, USA, daughter of Soloman SIRAH and Elizabeth LN-UNK. She was born about 1831 in Campbell County, Virginia, USA. She died about 1857 in Virginia, USA. He married (3) SYNTHIA MADELINE KELLY MOULES on 17 Sep 1862 in Franklin County, Virginia, USA, daughter of George MOULES and Elizabeth Ann KELLY. She was born on 20 Feb 1843 in Roanoke County, Virginia, USA. She died on 04 Jun 1916 in Henry County, Virginia, USA.
4- WILLIAM MCGUIRE was born in 1807 in Franklin County, Virginia, USA. He married (1) MAHALA HAMBRICK on 14 Apr 1834 in Franklin County, Virginia, USA. He married (2) HARRIETT GRIFFITH on 22 Feb 1862 in Franklin County, Virginia, USA. She was born in Franklin County, Virginia, USA.
1850 Census Franklin, VA McGuire, William/42/shoemaker…Mahala/42..Levi/15…Mary A./13…Louisa/13…Catharine/17
1850 Census Franklin Co., VA Hambrick, Samuel/25/farmer/$400..Elizabeth/61..McGuire, Nancy/9…Thomas/4
13 August 1814, Thomas Hambrick & Elizabeth Ferguson Surety, Jonathan Klingenpeel; married by Joseph Payne. 5- JOHN MCGUIRE JR was born in 1809 in Franklin County, Virginia, USA. He died about 1908. He married MARY HEWITT on 05 Jan 1842 in Botetourt County, Virginia, USA. She was born in 1810 in Botetourt County, Virginia, USA.
6- JOSEPH W 'JOSIAH' MCGUIRE was born in 1811 in Monroe County, Kentucky, USA. He died in Feb 1878 in Tompkinsville, Monroe County, Kentucky, USA.
He married NANCY FERGUSON on 03 Jan 1830 in Franklin County, Virginia, USA and had 10 children.
She was born in 1816 in Franklin County, Virginia, USA. She died about 1880 in Tompkinsville, Monroe County, Kentucky, and buried at Old Miller Cemetery,Drexal Holiway Farm,Monroe,KY
Note: The birth date is taken from the 1850 census. This makes Nancy about twelve when she married Joseph which seems too young. This is all we have to go on at this time. Possibly Nancy didn't remember the date she was born or the census taker recorded it incorrectly.
See also http://wc.rootsweb.ancestry.com/cgi-bin/igm.cgi?op=GET&db=:2091719&id=I2
7- JOSEPH MCGUIRE was born in 1815 in James River Community, Botetourt County, Virginia, USA. He died on 02 Jul 1846 in Louisville, Henderson County, Kentucky, USA. He married ELIZABETH GOFF on 10 Dec 1840 in Botetourt County, Virginia, USA. She was born in 1819 in Henderson County, Kentucky, USA.
8- JONATHAN MCGUIRE was born on 19 Oct 1816 in James River Community, Botetourt County, Virginia, USA. He died on 21 Mar 1908 in Gap Mills, Monroe County, West Virginia, USA. He married MARY JANE EDDY on 24 Feb 1839 in Botetourt County, Virginia, USA, daughter of Samuel Henry EDDY and Elizabeth Delilah EVANS. She was born on 04 Jul 1818 in Frederick County, Maryland, USA. She died on 26 May 1889 in Monroe County, Kentucky, USA.
9- MARK MCGUIRE was born in 1818 in Botetourt County, Virginia, USA. He died in 1915. He married MARTHA ELEANOR 'PATSY' HEWITT on 27 Oct 1838 in Botetourt County, Virginia, USA. She was born in 1819.

FRANCIS MCGUIRE was born on 07 Jul 1799 in Botetourt County, Virginia, USA. She died on 19 Mar 1881 in Bedford County, Virginia, USA. She married DANIEL DAVID AUSTIN
on 18 Jun 1834 in Botetourt County, Virginia, USA, son of Isaac R AUSTIN Sr and Martha G MALCOMB.
He was born about 1802 in Botetourt County, Virginia, USA. He died on 10 Mar 1881 in Bedford County, Virginia, USA.

Daniel David AUSTIN and Francis MCGUIRE had the following children:
1- NANCY ANN AUSTIN was born about 1837 in Botetourt County, Virginia, USA. She died on 13 Dec 1897 in Bedford County, Virginia, USA. She married THOMAS MILTON TOLLEY on 15 Feb 1860 in Bedford County, Virginia, USA. He was born in Feb 1830 in Bedford County, Virginia, USA. He died on 05 Jun 1900 in Bedford County, Virginia, USA.
2- JOHN HENRY AUSTIN was born about 1838 in Botetourt County, Virginia, USA. He died on 03 Jul 1876 in Bedford County, Virginia, USA. He married MARTHA JANE TOLLEY about 1867 in Bedford County, Virginia, USA, daughter of Archibald TOLLEY and Susan WORLEY. She was born about 1846 in Botetourt County, Virginia, USA. She died on 30 Oct 1934 in Covington, Alleghany, Virginia, USA.
3- EMMALINE AUSTIN was born about 1839 in Botetourt County, Virginia, USA.
4- WILLIAM R AUSTIN was born on 05 Oct 1840 in Botetourt, Virginia, USA. He died on 01 Mar 1931 in Waugh, Bedford County, Virginia, USA.
He married SUSAN PERTHINIA TOLLEY on 05 Apr 1860 in Bedford County, Virginia, USA, daughter of Joseph TOLLEY and Mary WORLEY.
She was born on 04 Apr 1839 in Bedford County, Virginia, USA. She died on 17 Apr 1915 in Bedford County, Virginia, USA.
5- JOSEPH AUSTIN was born about 1841 in Botetourt County, Virginia, USA.
6- FRANCIS A AUSTIN was born about 1846 in Botetourt County, Virginia, USA.
7- JAMES A AUSTIN was born about 1847 in Botetourt County, Virginia, USA.

WILLIAM R AUSTIN was born on 05 Oct 1840 in Botetourt, Virginia, USA. He died on 01 Mar 1931 in Waugh, Bedford County, Virginia, USA.
He married SUSAN PERTHINIA TOLLEY on 05 Apr 1860 in Bedford County, Virginia, USA, daughter of Joseph TOLLEY and Mary WORLEY.
She was born on 04 Apr 1839 in Bedford County, Virginia, USA. She died on 17 Apr 1915 in Bedford County, Virginia, USA.

William R AUSTIN and Susan Perthinia TOLLEY had the following children:
1- JOSEPH RICHARDSON AUSTIN SR was born about 1862 in Bedford County, Virginia, USA. He died in 1932 in Waughn Bedford County, Virginia, USA. He married SUSAN E RICE in 1888, daughter of James RICE and Laticia M LN-UNK. She was born about 1870 in Virginia, USA.
2- JOHN HENRY AUSTIN was born about 1864 in Bedford County, Virginia, USA.
3- MARY C AUSTIN was born about 1866 in Bedford County, Virginia, USA.
4- ELIZABETH AUSTIN was born about 1868 in Bedford County, Virginia, USA.
5- EMMA H AUSTIN was born in Sep 1872 in Bedford County, Virginia, USA. She died on 10 Dec 1873 in Bedford County, Virginia, USA.
6- WILLIE ANN AUSTIN was born on 11 Dec 1873 in Bedford County, Virginia, USA. She died on 01 Jul 1878 in Bedford County, Virginia, USA.
7- CASSIE B AUSTIN was born in Jan 1876 in Bedford County, Virginia, USA. She married ROBERT T WITT after 1910. He was born about 1876 in Virginia, USA.
8- FRANCIS AUSTIN was born in Mar 1886 in Bedford County, Virginia, USA.